BPC-157

LIMITED EVIDENCE

Also known as: Body Protection Compound 157

Investigational — not approved for human use

Educational Overview

A synthetic peptide derived from a sequence identified in gastric juice, studied in preclinical models for tissue and tendon repair.

Research Mechanism

Research explores effects on angiogenesis and growth-factor signaling in animal models; human mechanistic data is limited.

Areas of Study

Tendon/ligament healing (animal)
GI models (animal)

Safety Considerations

Human safety is not established. Sold as research material without pharmaceutical manufacturing oversight.

Frequently Asked Questions

Is BPC-157 approved?

No. It is investigational and not approved for human use.

Is there human evidence?

Controlled human trials are essentially absent; most data is animal or in vitro.

References

4 citations·no human trials identified

In vitro Verified

In cultured rat tendon fibroblasts, BPC-157 accelerated explant outgrowth and increased cell migration and survival under oxidative stress. Cell proliferation itself was not directly affected.

Chang CH, Tsai WC, Lin MS, Hsu YH, Pang JS. J Appl Physiol. 2011;110(3):774-80.PMID 21030672

Animal model Verified

In rats with surgically detached Achilles tendon, BPC-157 improved functional, biomechanical and histological healing markers, and reduced the healing impairment caused by corticosteroid co-treatment.

Krivic A, Anic T, Seiwerth S, Huljev D, Sikiric P. J Orthop Res. 2006;24(5):982-9.PMID 16583442

Animal model Verified

In a rat myotendinous junction defect that does not heal spontaneously, BPC-157 treatment was associated with recovered tissue organisation and reduced inflammatory infiltrate at 28 and 42 days.

Staresinic M, et al. Biomedicines. 2021;9(11):1547.PMID 34829776

Systematic review Verified

A systematic review of 36 studies published 1993-2024 concluded that BPC-157 improved outcomes in animal models of muscle, tendon, ligament and bone injury, while noting it is not FDA approved and is banned in some sports.

Vasireddi N, Hahamyan H, Salata MJ, et al. HSS Journal. 2025.DOI

Citations are provided for educational reference. Study findings describe what was observed under the stated conditions and model, and do not imply any effect in humans or any recommended use.

Last reviewed: 2026-06-01 · Status: draft · References verified by editorial review before publication.

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Disclaimer: Educational only. Not medical advice, diagnosis, or treatment. For research and educational purposes. Consult a licensed medical professional.