GHK-Cu

MODERATE EVIDENCE

Also known as: Copper peptide

Cosmetic and research use

Educational Overview

A copper-binding tripeptide studied primarily in topical/cosmetic contexts for skin.

Research Mechanism

Research explores roles in skin remodeling and antioxidant signaling; strongest data is topical.

Areas of Study

Topical skin studies (human)
Wound models (animal)

Safety Considerations

Topical cosmetic use is common; systemic/injected use is less studied.

Frequently Asked Questions

Is GHK-Cu in skincare?

Yes, copper peptides appear in many topical cosmetic products.

References

3 citations·2 with human data

Review Verified

A review of gene-expression data describing GHK-Cu's studied effects on collagen, elastin and glycosaminoglycan synthesis and on dermal fibroblast function.

Pickart L, Margolina A. Int J Mol Sci. 2018;19(7):1987.PMID 29986520

Human RCT Awaiting verification

A double-blind randomised controlled trial of a cosmetic anti-ageing product reporting improvement in photoaged skin. Note that the product was a multi-ingredient formulation, so the effect cannot be attributed to GHK-Cu alone.

Watson REB, Ogden S, Cotterell LF, et al. Br J Dermatol. 2009;161(2):419-26.PMID 19438432

Human RCT Verified

A registered randomised vehicle-controlled trial evaluating topical GHK-Cu gel on standardised punch-biopsy wounds in healthy adults. Registration confirms the trial exists; results are not yet reported.

Topical GHK-Cu Gel for Acute Skin Wound Healing. ClinicalTrials.gov.NCT07437586

Citations are provided for educational reference. Study findings describe what was observed under the stated conditions and model, and do not imply any effect in humans or any recommended use.

Last reviewed: 2026-06-01 · Status: draft · References verified by editorial review before publication.

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Disclaimer: Educational only. Not medical advice, diagnosis, or treatment. For research and educational purposes. Consult a licensed medical professional.