NAD+
MODERATE EVIDENCEAlso known as: Nicotinamide adenine dinucleotide
Sold as a supplement/research material; IV and injectable use is not FDA-approved
Educational Overview
A coenzyme central to cellular energy metabolism. Precursors are widely studied; direct NAD+ administration is less well characterised.
Research Mechanism
Central to redox reactions and sirtuin/PARP activity. Most human data concerns oral precursors (NR, NMN) rather than injected NAD+.
Areas of Study
- Precursor supplementation (human trials)
- Ageing biology (preclinical)
Safety Considerations
Oral precursors are generally well tolerated in studies. Injectable/IV NAD+ is not an approved therapy and is less studied.
Frequently Asked Questions
Does NAD+ reverse ageing?
No. Research is active and interesting, but claims of reversing ageing outrun the human evidence.
References
References pending editorial review
We publish citations only after a qualified reviewer has verified them against the primary literature. We do not list references we have not checked. (1 queued.)
Last reviewed: 2026-06-01 · Status: draft · References verified by editorial review before publication.
Disclaimer: Educational only. Not medical advice, diagnosis, or treatment. For research and educational purposes. Consult a licensed medical professional.